At about 12:40 a.m. Thursday, the 18-wheeler was traveling in the southbound lanes when it veered off the right side of the road at the south split where I-65 meets I-70.
The semi slammed into a guardrail and overturned, Indiana State Police reported.
The driver, a 30-year-old male, was trapped beneath the big truck. His passenger, a 33-year-old man, was ejected.
Both victims of the crash were taken to Wishard Memorial Hospital.
The driver was pronounced dead at 3:29 a.m. His passenger’s condition was unknown.
Troopers said the semi was speeding and that the driver might have dozed off.
The truck has been carrying empty CD cases, which spilled onto the highway during the crash. Southbound I-65 lanes were closed for over 5:00 hours while the debris was cleaned up.